Contraindication
A condition or circumstance that makes a particular drug inadvisable because the risk of harm outweighs the benefit. Contraindications may be absolute (never use) or relative (use with caution). GLP-1 receptor agonists are contraindicated in patients with a history of medullary thyroid carcinoma.
Technical Context
Absolute contraindications (must never use): personal or family history of medullary thyroid carcinoma or MEN2 (GLP-1 RAs), known hypersensitivity to the drug or any excipient, pregnancy (many peptide drugs including GnRH compounds), and active malignancy for growth-promoting peptides (GH, IGF-1). Relative contraindications (use with caution, benefit must clearly outweigh risk): history of pancreatitis (GLP-1 RAs), severe gastroparesis (GLP-1 RAs), severe renal impairment (dose adjustment may be needed), diabetic retinopathy (risk of temporary worsening with rapid glucose improvement — semaglutide SUSTAIN-6 signal). Contraindications are listed in Section 4 of the PI (US) and Section 4.3 of the SmPC (EU). Off-label use that violates absolute contraindications exposes the prescriber to significant liability.